In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1.
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ABSTRACT:
SUBMITTER: Mitsuhashi T
PROVIDER: S-EPMC2941332 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1.
Mitsuhashi Takayuki T Yonemoto Junzo J Sone Hideko H Kosuge Yasuhiro Y Kosaki Kenjiro K Takahashi Takao T
Proceedings of the National Academy of Sciences of the United States of America 20100830 37
Dioxins have been reported to exert various adverse effects, including cell-cycle dysregulation in vitro and impairment of spatial learning and memory after in utero exposure in rodents. Furthermore, children born to mothers who are exposed to dioxin analogs polychlorinated dibenzofurans or polychlorinated biphenyls have developmental impairments in cognitive functions. Here, we show that in utero exposure to dioxins in mice alters differentiation patterns of neural progenitors and leads to decr ...[more]
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