Ontology highlight
ABSTRACT:
SUBMITTER: Wartmann T
PROVIDER: S-EPMC2941736 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Wartmann Thomas T Mayerle Julia J Kähne Thilo T Sahin-Tóth Miklós M Ruthenbürger Manuel M Matthias Rainer R Kruse Anne A Reinheckel Thomas T Peters Christoph C Weiss F Ulrich FU Sendler Matthias M Sendler Matthias M Lippert Hans H Schulz Hans-Ulrich HU Aghdassi Ali A Dummer Annegret A Teller Steffen S Halangk Walter W Lerch Markus M MM
Gastroenterology 20091110 2
<h4>Background & aims</h4>Acute pancreatitis is characterized by an activation cascade of digestive enzymes in the pancreas. The first of these, trypsinogen, can be converted to active trypsin by the peptidase cathepsin B (CTSB). We investigated whether cathepsin L (CTSL) can also process trypsinogen to active trypsin and has a role in pancreatitis.<h4>Methods</h4>In CTSL-deficient (Ctsl(-/-)) mice, pancreatitis was induced by injection of cerulein or infusion of taurocholate into the pancreatic ...[more]