Ontology highlight
ABSTRACT:
SUBMITTER: Totrov M
PROVIDER: S-EPMC2942080 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Virology 20100721 2
V3 loop is a major neutralizing determinant of the HIV-1 gp120. Using 3D structures of cholera toxin B subunit (CTB), complete V3 in the gp120 context, and V3 bound to a monoclonal antibody (mAb), we designed two V3-scaffold immunogen constructs (V3-CTB). The full-length V3-CTB presenting the complete V3 in a structural context mimicking gp120 was recognized by the large majority of our panel of 24 mAbs. The short V3-CTB presenting a V3 fragment in the conformation observed in the complex with t ...[more]