Ontology highlight
ABSTRACT:
SUBMITTER: Mitrophanov AY
PROVIDER: S-EPMC2942797 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Mitrophanov Alexander Y AY Hadley Tricia J TJ Groisman Eduardo A EA
Journal of molecular biology 20100630 4
Positive feedback loops are regulatory elements that can modulate expression output, kinetics and noise in genetic circuits. Transcriptional regulators participating in such loops are often expressed from two promoters, one constitutive and one autoregulated. Here, we investigate the interplay of promoter strengths and the intensity of the stimulus activating the transcriptional regulator in defining the output of a positively autoregulated genetic circuit. Using a mathematical model of two-comp ...[more]