Ontology highlight
ABSTRACT:
SUBMITTER: Mohan S
PROVIDER: S-EPMC2942958 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Mohan Shekher S Davis Randall L RL DeSilva Udaya U Stevens Craig W CW
Journal of neuroimmunology 20100707 1-2
Treatment of SK-N-SH cells with morphine and interleukin-1beta (IL-1β) produced dual regulation of the mRNA for the human mu opioid receptor (MOR) protein. Morphine produced a decrease in the MOR mRNA while IL-1β increased it, as assessed by real-time quantitative PCR. These data were consistent with immunocytochemical studies of treated and untreated cells. Morphine-mediated down-regulation of MOR was blocked by naltrexone and IL-1β-induced up-regulation of MOR was blocked by interleukin-1 rece ...[more]