Ontology highlight
ABSTRACT:
SUBMITTER: Khan QJ
PROVIDER: S-EPMC2943085 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Khan Qamar J QJ O'Dea Anne P AP Sharma Priyanka P
Journal of oncology 20100824
Musculoskeletal symptoms including arthralgia and myalgia occur frequently in aging women, particularly during the transition to menopause, when plasma estrogens precipitously decline. In postmenopausal women (PMW) with breast cancer, third-generation aromatase inhibitors (AIs) as adjuvant hormonal therapy have proven to be more effective, and to have a more predictable side effect profile, than tamoxifen. However, AIs further reduce plasma estrogens in PMW, exacerbating musculoskeletal symptoms ...[more]