Ontology highlight
ABSTRACT:
SUBMITTER: Khorosjutina O
PROVIDER: S-EPMC2943280 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Khorosjutina Olga O Wanrooij Paulina H PH Walfridsson Julian J Szilagyi Zsolt Z Zhu Xuefeng X Baraznenok Vera V Ekwall Karl K Gustafsson Claes M CM
The Journal of biological chemistry 20100709 39
The multiprotein Mediator complex is an important regulator of RNA polymerase II-dependent genes in eukaryotic cells. In contrast to the situation in many other eukaryotes, the conserved Med15 protein is not a stable component of Mediator isolated from fission yeast. We here demonstrate that Med15 exists in a protein complex together with Hrp1, a CHD1 ATP-dependent chromatin-remodeling protein. The Med15-Hrp1 subcomplex is not a component of the core Mediator complex but can interact with the L- ...[more]