Ontology highlight
ABSTRACT:
SUBMITTER: Jaoko W
PROVIDER: S-EPMC2943475 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Jaoko Walter W Karita Etienne E Kayitenkore Kayitesi K Omosa-Manyonyi Gloria G Allen Susan S Than Soe S Adams Elizabeth M EM Graham Barney S BS Koup Richard A RA Bailer Robert T RT Smith Carol C Dally Len L Farah Bashir B Anzala Omu O Muvunyi Claude M CM Bizimana Jean J Tarragona-Fiol Tony T Bergin Philip J PJ Hayes Peter P Ho Martin M Loughran Kelley K Komaroff Wendy W Stevens Gwynneth G Thomson Helen H Boaz Mark J MJ Cox Josephine H JH Schmidt Claudia C Gilmour Jill J Nabel Gary J GJ Fast Patricia P Bwayo Job J
PloS one 20100921 9
<h4>Background</h4>We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector expressing HIV-1 Gag and Pol from subtype B and Env from subtypes A, B and C, given alone or as boost following a DNA plasmid vaccine expressing the same HIV-1 proteins plus Nef, in 114 healthy HIV-uninfected African adults.<h4>Methodology/principal findings</h4>Volunteers were randomized to 4 groups receiving the rAd5 vaccine intramu ...[more]