Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.
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ABSTRACT:
SUBMITTER: Lajoie S
PROVIDER: S-EPMC2943538 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
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Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.
Lajoie Stephane S Lewkowich Ian P IP Suzuki Yusuke Y Clark Jennifer R JR Sproles Alyssa A AA Dienger Krista K Budelsky Alison L AL Wills-Karp Marsha M
Nature immunology 20100829 10
Severe asthma is associated with the production of interleukin 17A (IL-17A). The exact role of IL-17A in severe asthma and the factors that drive its production are unknown. Here we demonstrate that IL-17A mediated severe airway hyperresponsiveness (AHR) in susceptible strains of mice by enhancing IL-13-driven responses. Mechanistically, we demonstrate that IL-17A and AHR were regulated by allergen-driven production of anaphylatoxins, as mouse strains deficient in complement factor 5 (C5) or the ...[more]
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