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Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.


ABSTRACT: A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.

SUBMITTER: Wolpin BM 

PROVIDER: S-EPMC2943735 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.

Wolpin Brian M BM   Kraft Peter P   Gross Myron M   Helzlsouer Kathy K   Bueno-de-Mesquita H Bas HB   Steplowski Emily E   Stolzenberg-Solomon Rachael Z RZ   Arslan Alan A AA   Jacobs Eric J EJ   Lacroix Andrea A   Petersen Gloria G   Zheng Wei W   Albanes Demetrius D   Allen Naomi E NE   Amundadottir Laufey L   Anderson Garnet G   Boutron-Ruault Marie-Christine MC   Buring Julie E JE   Canzian Federico F   Chanock Stephen J SJ   Clipp Sandra S   Gaziano John Michael JM   Giovannucci Edward L EL   Hallmans Göran G   Hankinson Susan E SE   Hoover Robert N RN   Hunter David J DJ   Hutchinson Amy A   Jacobs Kevin K   Kooperberg Charles C   Lynch Shannon M SM   Mendelsohn Julie B JB   Michaud Dominique S DS   Overvad Kim K   Patel Alpa V AV   Rajkovic Aleksandar A   Sanchéz Maria-José MJ   Shu Xiao-Ou XO   Slimani Nadia N   Thomas Gilles G   Tobias Geoffrey S GS   Trichopoulos Dimitrios D   Vineis Paolo P   Virtamo Jarmo J   Wactawski-Wende Jean J   Yu Kai K   Zeleniuch-Jacquotte Anne A   Hartge Patricia P   Fuchs Charles S CS  

Cancer research 20100126 3


A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using l  ...[more]

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