Ontology highlight
ABSTRACT:
SUBMITTER: Adamson DC
PROVIDER: S-EPMC2943736 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Adamson David C DC Shi Qun Q Wortham Matthew M Northcott Paul A PA Di Chunhui C Duncan Christopher G CG Li Jianjun J McLendon Roger E RE Bigner Darell D DD Taylor Michael D MD Yan Hai H
Cancer research 20091222 1
OTX2 is a developmentally regulated transcription factor involved in early morphogenesis of the central nervous system. This gene is amplified and overexpressed in medulloblastoma cell lines, but the nature and extent of its genetic alterations in primary tumors have not been evaluated. Analysis of a large cohort of primary medulloblastomas revealed frequent focal copy number gain of a region minimally containing OTX2 as a single gene. OTX2 copy number gain was restricted to tumor subtypes that ...[more]