Natural mutagenesis of human genomes by endogenous retrotransposons.
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ABSTRACT:
SUBMITTER: Iskow RC
PROVIDER: S-EPMC2943760 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Natural mutagenesis of human genomes by endogenous retrotransposons.
Iskow Rebecca C RC McCabe Michael T MT Mills Ryan E RE Torene Spencer S Pittard W Stephen WS Neuwald Andrew F AF Van Meir Erwin G EG Vertino Paula M PM Devine Scott E SE
Cell 20100601 7
Two abundant classes of mobile elements, namely Alu and L1 elements, continue to generate new retrotransposon insertions in human genomes. Estimates suggest that these elements have generated millions of new germline insertions in individual human genomes worldwide. Unfortunately, current technologies are not capable of detecting most of these young insertions, and the true extent of germline mutagenesis by endogenous human retrotransposons has been difficult to examine. Here, we describe techno ...[more]
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