Ontology highlight
ABSTRACT:
SUBMITTER: Chanda D
PROVIDER: S-EPMC2943933 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Chanda Diptiman D Isayeva Tatyana T Kumar Sanjay S Hensel Jonathan A JA Sawant Anandi A Ramaswamy Girish G Siegal Gene P GP Beatty Matthew S MS Ponnazhagan Selvarangan S
Clinical cancer research : an official journal of the American Association for Cancer Research 20091117 23
<h4>Purpose</h4>Current evidence indicates that an osteoblast lesion in prostate cancer is preceded by osteolysis. Thus, prevention of osteolysis would reduce complications of bone metastasis. Bone marrow-derived mesenchymal stem cells have the ability to differentiate into osteoblast and produce osteoprotegerin, a decoy receptor for the receptor activator for nuclear factor kappaB ligand, naturally. The present study examined the potential of unmodified mesenchymal stem cells to prevent osteoly ...[more]