Ontology highlight
ABSTRACT:
SUBMITTER: Polo SE
PROVIDER: S-EPMC2944064 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
The EMBO journal 20100806 18
The chromatin remodelling factor chromodomain helicase DNA-binding protein 4 (CHD4) is a catalytic subunit of the NuRD transcriptional repressor complex. Here, we reveal novel functions for CHD4 in the DNA-damage response (DDR) and cell-cycle control. We show that CHD4 mediates rapid poly(ADP-ribose)-dependent recruitment of the NuRD complex to DNA-damage sites, and we identify CHD4 as a phosphorylation target for the apical DDR kinase ataxia-telangiectasia mutated. Functionally, we show that CH ...[more]