Ontology highlight
ABSTRACT:
SUBMITTER: Varlamov O
PROVIDER: S-EPMC2944284 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Varlamov Oleg O Somwar Romel R Cornea Anda A Kievit Paul P Grove Kevin L KL Roberts Charles T CT
American journal of physiology. Endocrinology and metabolism 20100622 3
Increased body fat correlates with the enlargement of average fat cell size and reduced adipose tissue insulin sensitivity. It is currently unclear whether adipocytes, as they accumulate more triglycerides and grow in size, gradually become less insulin sensitive or whether obesity-related factors independently cause both the enlargement of adipocyte size and reduced adipose tissue insulin sensitivity. In the first instance, large and small adipocytes in the same tissue would exhibit differences ...[more]