Ontology highlight
ABSTRACT:
SUBMITTER: Avramopoulos D
PROVIDER: S-EPMC2945399 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Avramopoulos Dimitrios D Szymanski Megan M Wang Ruihua R Bassett Susan S
Neurobiology of aging 20100608 12
Alzheimer's disease (AD) is a common cause of dementia with a strong genetic component and risk sharply increasing with age. We performed two parallel microarray experiments to independently identify genes involved in normal aging and genes involved in AD using RNA extracted from the temporal lobe of 22 late onset AD and 23 control brain donors. We found that AD is accompanied by significant changes in the expression of many genes with upregulation of genes involved in inflammation and in transc ...[more]