Ontology highlight
ABSTRACT:
SUBMITTER: Samadi AK
PROVIDER: S-EPMC2945430 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Samadi Abbas K AK Tong Xiaoqin X Mukerji Ridhwi R Zhang Huaping H Timmermann Barbara N BN Cohen Mark S MS
Journal of natural products 20100901 9
As part of a program to discover drug leads from plant biodiversity, the present investigation was undertaken to explore the anticancer potential of compounds derived from selected Latin American plants. Bioassay-guided fractionation of a crude extract of the aerial parts of Vassobia breviflora led to the isolation of the withanolide-type steroidal lactone withaferin A (1). This compound was tested for antiproliferative activity against the head and neck squamous cell carcinoma (HNSCC) cell line ...[more]