Ontology highlight
ABSTRACT:
SUBMITTER: Wetmore DR
PROVIDER: S-EPMC2945545 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Wetmore Diana R DR Joseloff Elizabeth E Pilewski Joseph J Lee Douglas P DP Lawton Kay A KA Mitchell Matthew W MW Milburn Michael V MV Ryals John A JA Guo Lining L
The Journal of biological chemistry 20100730 40
Cystic fibrosis (CF) is a life-shortening disease caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. To gain an understanding of the epithelial dysfunction associated with CF mutations and discover biomarkers for therapeutics development, untargeted metabolomic analysis was performed on primary human airway epithelial cell cultures from three separate cohorts of CF patients and non-CF subjects. Statistical analysis revealed a set of reproducible and sign ...[more]