Ontology highlight
ABSTRACT:
SUBMITTER: Kamiya Y
PROVIDER: S-EPMC2945574 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Kamiya Yuto Y Miyazono Kohei K Miyazawa Keiji K
The Journal of biological chemistry 20100727 40
The inhibitory Smads (I-Smads), i.e. Smad6 and Smad7, are negative regulators of transforming growth factor-β (TGF-β) family signaling. I-Smads inhibit TGF-β family signaling principally through physical interaction with type I receptors (activin receptor-like kinases), so as to compete with receptor-regulated Smads (R-Smads) for activation. However, how I-Smads interact with type I receptors is not well understood. In the present study, we found that Smad7 has two modes of interaction with type ...[more]