Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC2945597 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20100701 40
Generation of induced pluripotent stem cells from somatic cells using defined factors has potential relevant applications in regenerative medicine and biology. However, this promising technology remains inefficient and time consuming. We have devised a serum free culture medium termed iSF1 that facilitates the generation of mouse induced pluripotent stem cells. This optimization of the culture medium is sensitive to the presence of Myc in the reprogramming factors. Moreover, we could reprogram m ...[more]