Tumor-initiating cells are rare in many human tumors.
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ABSTRACT:
SUBMITTER: Ishizawa K
PROVIDER: S-EPMC2945729 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Tumor-initiating cells are rare in many human tumors.
Ishizawa Kota K Rasheed Zeshaan A ZA Karisch Robert R Wang Qiuju Q Kowalski Jeanne J Susky Erica E Pereira Keira K Karamboulas Christina C Moghal Nadeem N Rajeshkumar N V NV Hidalgo Manuel M Tsao Ming M Ailles Laurie L Waddell Thomas K TK Maitra Anirban A Neel Benjamin G BG Matsui William W
Cell stem cell 20100901 3
Tumor-initiating cells (TICs) are defined by their ability to form tumors after xenotransplantation in immunodeficient mice and appear to be relatively rare in most human cancers. Recent data in melanoma indicate that the frequency of TICs increases dramatically via more permissive xenotransplantation conditions, raising the possibility that the true frequency of TICs has been greatly underestimated in most human tumors. We compared the growth of human pancreatic, non-small cell lung, and head a ...[more]
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