SVA retrotransposons: Evolution and genetic instability.
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ABSTRACT:
SUBMITTER: Hancks DC
PROVIDER: S-EPMC2945828 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
SVA retrotransposons: Evolution and genetic instability.
Hancks Dustin C DC Kazazian Haig H HH
Seminars in cancer biology 20100421 4
SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are associated with disease in humans. SVAs are evolutionarily young and presumably mobilized by the LINE-1 reverse transcriptase in trans. SVAs are currently active and may impact the host through a variety of mechanisms including insertional mutagenesis, exon shuffling, alternative splicing, and the generation of differentially methylated regions (DMR). Here we review SVA biology, including SVA insertions associated ...[more]
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