Ontology highlight
ABSTRACT:
SUBMITTER: Zhao C
PROVIDER: S-EPMC2946231 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Zhao Chen C Chen Alan A Jamieson Catriona H CH Fereshteh Mark M Abrahamsson Annelie A Blum Jordan J Kwon Hyog Young HY Kim Jynho J Chute John P JP Rizzieri David D Munchhof Michael M VanArsdale Todd T Beachy Philip A PA Reya Tannishtha T
Nature 20090401 7239
Although the role of Hedgehog (Hh) signalling in embryonic pattern formation is well established, its functions in adult tissue renewal and maintenance remain unclear, and the relationship of these functions to cancer development has not been determined. Here we show that the loss of Smoothened (Smo), an essential component of the Hh pathway, impairs haematopoietic stem cell renewal and decreases induction of chronic myelogenous leukaemia (CML) by the BCR-ABL1 oncoprotein. Loss of Smo causes dep ...[more]