Ontology highlight
ABSTRACT:
SUBMITTER: Wilson MC
PROVIDER: S-EPMC2946249 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100901 36
Saliniketals A and B are unusual polyketides from the marine actinomycete Salinispora arenicola that inhibit ornithine decarboxylase induction. The structural similarities between the saliniketals and the ansa chain of the potent rifamycin antibiotics, which co-occur in the fermentation broth, suggest a common origin between the two compound classes. Using PCR-directed mutagenesis, chemical complementation studies, and stable isotope feeding experiments, we showed that the saliniketals are bypro ...[more]