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International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers.

ABSTRACT: To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers.Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed.Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver.These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well-defined and approved imaging and analysis techniques are used.

SUBMITTER: Kirk P

PROVIDER: S-EPMC2946327 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers.

Kirk Paul P He Taigang T Anderson Lisa J LJ Roughton Michael M Tanner Mark A MA Lam Wynnie W M WW Au Wing Y WY Chu Winnie C W WC Chan Godfrey G Galanello Renzo R Matta Gildo G Fogel Mark M Cohen Alan R AR Tan Ru San RS Chen Kevin K Ng Ivy I Lai Angie A Fucharoen Suthat S Laothamata Jiraporn J Chuncharunee Suporn S Jongjirasiri Sutipong S Firmin David N DN Smith Gillian C GC Pennell Dudley J DJ

Journal of magnetic resonance imaging : JMRI 20100801 2

<h4>Purpose</h4>To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers.<h4>Materials and methods</h4>Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was als ...[more]

PMID: 20677256

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Project description:To evaluate T2 and T2* changes in acute reperfused hemorrhagic and nonhemorrhagic myocardial infarctions and to determine which technique is more suitable in the detection of intramyocardial hemorrhage at 1.5 T.Patient studies were approved by the institutional review board and were HIPAA compliant. Patients (n = 14, three women) with first ST-elevation myocardial infarction underwent cardiac magnetic resonance (MR) imaging 3 days after angioplasty. T2* maps, T2 short inversion time inversion-recovery (STIR) images, and late gadolinium enhancement (LGE) images were acquired. Animal studies were approved by the institutional animal care and use committee. Canines (n = 20) were subjected to ischemia-reperfusion injury, and cardiac MR imaging was performed 5 days after reperfusion. T2* and T2 maps and T2 STIR and LGE images were acquired. Repeated-measures analysis of variance or the Friedman test was used to compare T2 and T2* changes in patients with hemorrhagic infarctions and those with nonhemorrhagic infarctions.Relative to remote myocardium, mean T2* of hemorrhagic infarctions was 54% ± 13 (standard deviation) lower in patients (15.9 msec ± 4.5 vs 35.2 msec ± 2.1, P < .001) and 40% ± 10 lower in canines (23.0 msec ± 4.0 vs 39.3 msec ± 2.5, P < .001). Mean T2* of nonhemorrhagic infarctions was marginally elevated by 6% ± 2.5 (37.8 msec ± 2.5, P = .021) in patients and by 8% ± 5 (44.6 msec ± 4.8, P = .012) in canines. In contrast, mean T2 STIR signal intensity (SI) of both hemorrhagic infarctions and nonhemorrhagic infarctions was higher than that in remote myocardium both in patients (hemorrhagic: 37% ± 19, P < .001; nonhemorrhagic: 78% ± 27, P < .001) and in canines (hemorrhagic: 42% ± 22, P < .001; nonhemorrhagic: 65% ± 22, P < .001). Consistent with STIR SI findings, mean T2 of both hemorrhagic (62.0 msec ± 4.9) and nonhemorrhagic (71.7 msec ± 7.3) infarctions in canines was elevated relative to mean T2 of remote myocardium (52.1 msec ± 4.8) by 18% ± 9 and 38% ± 13, respectively (P < .001 for both).T2* cardiac MR imaging is more suitable than T2 cardiac MR imaging in the detection and characterization of acute reperfusion myocardial hemorrhage.http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.13122397/-/DC1.

Dataset Information

International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers.

Publications

International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers.

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