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Ultrasensitive mycotoxin detection by STING sensors.

ABSTRACT: Signal transduction by ion nano-gating (STING) technology is a label-free biosensor capable of identifying DNA and proteins. Based on a functionalized quartz nanopipette, the STING sensor includes specific recognition elements for analyte discrimination based on size, shape and charge density. A key feature of this technology is that it does not require any nanofabrication facility; each nanopipette can be easily, reproducibly, and inexpensively fabricated and tailored at the bench, thus reducing the cost and the turnaround time. Here, we show that STING sensors are capable of the ultrasensitive detection of HT-2 toxin with a detection limit of 100 fg/ml and compare the STING capabilities with respect to conventional sandwich assay techniques.

SUBMITTER: Actis P

PROVIDER: S-EPMC2946441 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Ultrasensitive mycotoxin detection by STING sensors.

Actis Paolo P Jejelowo Olufisayo O Pourmand Nader N

Biosensors & bioelectronics 20100819 2

Signal transduction by ion nano-gating (STING) technology is a label-free biosensor capable of identifying DNA and proteins. Based on a functionalized quartz nanopipette, the STING sensor includes specific recognition elements for analyte discrimination based on size, shape and charge density. A key feature of this technology is that it does not require any nanofabrication facility; each nanopipette can be easily, reproducibly, and inexpensively fabricated and tailored at the bench, thus reducin ...[more]

PMID: 20829024

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