Ontology highlight
ABSTRACT:
SUBMITTER: Wanders RJ
PROVIDER: S-EPMC2946543 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Wanders Ronald J A RJ Ruiter Jos P N JP IJLst Lodewijk L Waterham Hans R HR Houten Sander M SM
Journal of inherited metabolic disease 20100520 5
Oxidation of fatty acids in mitochondria is a key physiological process in higher eukaryotes including humans. The importance of the mitochondrial beta-oxidation system in humans is exemplified by the existence of a group of genetic diseases in man caused by an impairment in the mitochondrial oxidation of fatty acids. Identification of patients with a defect in mitochondrial beta-oxidation has long remained notoriously difficult, but the introduction of tandem-mass spectrometry in laboratories f ...[more]