Ontology highlight
ABSTRACT:
SUBMITTER: Duewell P
PROVIDER: S-EPMC2946640 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Nature 20100401 7293
The inflammatory nature of atherosclerosis is well established but the agent(s) that incite inflammation in the artery wall remain largely unknown. Germ-free animals are susceptible to atherosclerosis, suggesting that endogenous substances initiate the inflammation. Mature atherosclerotic lesions contain macroscopic deposits of cholesterol crystals in the necrotic core, but their appearance late in atherogenesis had been thought to disqualify them as primary inflammatory stimuli. However, using ...[more]