Ontology highlight
ABSTRACT:
SUBMITTER: Elrod JW
PROVIDER: S-EPMC2947235 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Elrod John W JW Wong Renee R Mishra Shikha S Vagnozzi Ronald J RJ Sakthievel Bhuvana B Goonasekera Sanjeewa A SA Karch Jason J Gabel Scott S Farber John J Force Thomas T Brown Joan Heller JH Murphy Elizabeth E Molkentin Jeffery D JD
The Journal of clinical investigation 20100920 10
Cyclophilin D (which is encoded by the Ppif gene) is a mitochondrial matrix peptidyl-prolyl isomerase known to modulate opening of the mitochondrial permeability transition pore (MPTP). Apart from regulating necrotic cell death, the physiologic function of the MPTP is largely unknown. Here we have shown that Ppif(-/-) mice exhibit substantially greater cardiac hypertrophy, fibrosis, and reduction in myocardial function in response to pressure overload stimulation than control mice. In addition, ...[more]