Ontology highlight
ABSTRACT:
SUBMITTER: Raitila A
PROVIDER: S-EPMC2947291 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Raitila Anniina A Lehtonen Heli J HJ Arola Johanna J Heliövaara Elina E Ahlsten Manuel M Georgitsi Marianthi M Jalanko Anu A Paetau Anders A Aaltonen Lauri A LA Karhu Auli A
The American journal of pathology 20100813 4
Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been shown to predispose to pituitary adenoma predisposition, a condition characterized by growth hormone (GH)-secreting pituitary tumors. To study AIP-mediated tumorigenesis, we generated an Aip mouse model. Heterozygous mice developed normally but were prone to pituitary adenomas, in particular to those secreting GH. A complete loss of AIP was detected in these lesions, and full penetrance was reached at the age of ...[more]