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Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13.

ABSTRACT: Patients with acute myeloid leukemia (AML) frequently fail chemotherapy due to refractory disease, relapse, or toxicity. Among older AML patients (age > 60 years), there are few long-term survivors. Lenalidomide is a candidate for study in AML based on its clinical activity in a related disorder, myelodysplastic syndrome (MDS), with the 5q- chromosomal abnormality. We report induction of sustained morphologic and cytogenetic complete remission in 2 older AML patients treated with high-dose, single-agent lenalidomide; each patient had trisomy 13 as the sole cytogenetic abnormality. We show for the first time that lenalidomide has clinical activity in this poor-risk cytogenetic subset of AML. The clinical trials described in this paper have been registered with www.clinicaltrials.gov under identifiers NCT00466895 and NCT00546897.

SUBMITTER: Fehniger TA

PROVIDER: S-EPMC2947363 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13.

Fehniger Todd A TA Byrd John C JC Marcucci Guido G Abboud Camille N CN Kefauver Cheryl C Payton Jacqueline E JE Vij Ravi R Blum William W

Blood 20080929 5

Patients with acute myeloid leukemia (AML) frequently fail chemotherapy due to refractory disease, relapse, or toxicity. Among older AML patients (age > 60 years), there are few long-term survivors. Lenalidomide is a candidate for study in AML based on its clinical activity in a related disorder, myelodysplastic syndrome (MDS), with the 5q- chromosomal abnormality. We report induction of sustained morphologic and cytogenetic complete remission in 2 older AML patients treated with high-dose, sing ...[more]

PMID: 18824593

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