Ontology highlight
ABSTRACT:
SUBMITTER: Choubey D
PROVIDER: S-EPMC2947464 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Choubey Divaker D Duan Xin X Dickerson Eric E Ponomareva Larissa L Panchanathan Ravichandran R Shen Hui H Srivastava Ratika R
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20100601 6
Deregulated innate immune responses that result in increased levels of type I interferons (IFNs) and stimulation of IFN-inducible genes are thought to contribute to chronic inflammation and autoimmunity. One family of IFN-inducible genes is the Ifi200 family, which includes the murine (eg, Ifi202a, Ifi202b, Ifi203, Ifi204, Mndal, and Aim2) and human (eg, IFI16, MNDA, IFIX, and AIM2) genes. Genes in the family encode structurally related proteins (the p200-family proteins), which share at least o ...[more]