Ontology highlight
ABSTRACT:
SUBMITTER: Polychronidou M
PROVIDER: S-EPMC2947476 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Polychronidou Maria M Hellwig Andrea A Grosshans Jörg J
Molecular biology of the cell 20100804 19
Nuclear shape changes are observed during a variety of developmental processes, pathological conditions, and ageing. The mechanisms underlying nuclear shape changes in the above-mentioned situations have mostly remained unclear. To address the molecular mechanism behind nuclear shape changes, we analyzed how the farnesylated nuclear envelope proteins Kugelkern and lamin Dm0 affect the structure of the nuclear membrane. We found that Kugelkern and lamin Dm0 affect nuclear shape without requiring ...[more]