Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population.

ABSTRACT:

Background and methodology

The 719Arg allele of KIF6 (rs20455) was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with non-fatal myocardial infarction (MI) in a case-control study of an admixed population from the Central Valley of Costa Rica. Genotypes of the KIF6 variant were determined for 4,134 men and women. Cases (1,987) had survived a first MI; controls (2,147) had no history of MI and were matched to cases by age, sex, and area of residence. We tested the association between the KIF6 719Arg allele and non-fatal MI by conditional logistic regression and adjusted for admixture of founder populations.

Principal findings

Compared with the reference Trp/Trp homozygotes, KIF6 7

SUBMITTER: Bare LA 

PROVIDER: S-EPMC2947524 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature