Blood pressure and human genetic variation in the general population.
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ABSTRACT:
SUBMITTER: Arora P
PROVIDER: S-EPMC2947583 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Blood pressure and human genetic variation in the general population.
Arora Pankaj P Newton-Cheh Christopher C
Current opinion in cardiology 20100501 3
<h4>Purpose of review</h4>Hypertension is a complex trait with multiple environmental and genetic contributors. Until recently, linkage studies of rare Mendelian disorders of hypertension and hypotension have produced the most notable progress toward understanding the heritable basis of blood pressure (BP). Association studies to identify common variants have been limited in the past by small sample sizes and most findings have lacked replication.<h4>Recent findings</h4>Recently, well powered, t ...[more]
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