Clarke's column neurons as the focus of a corticospinal corollary circuit.

ABSTRACT: Proprioceptive sensory signals inform the CNS of the consequences of motor acts, but effective motor planning involves internal neural systems capable of anticipating actual sensory feedback. Just where and how predictive systems exert their influence remains poorly understood. We explored the possibility that spinocerebellar neurons that convey proprioceptive sensory information also integrate information from cortical command systems. Analysis of the circuitry and physiology of identified dorsal spinocerebellar tract neurons in mouse spinal cord revealed distinct populations of Clarke's column neurons that received direct excitatory and/or indirect inhibitory inputs from descending corticospinal axons. The convergence of these descending inhibitory and excitatory inputs to Clarke's colum

SUBMITTER: Hantman AW 

PROVIDER: S-EPMC2947611 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature