The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms.
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ABSTRACT:
SUBMITTER: Pinczewski J
PROVIDER: S-EPMC2947742 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms.
Pinczewski Joel J Slominski Andrzej A
Experimental dermatology 20101001 10
Hormonally active vitamin D3, 1,25-(OH)2D3, is believed to have a role in the prevention of cancer formation and in limiting the aggressiveness of cancers that do arise. Therefore,much interest is presently being focused on 1,25-(OH)2D3 and its analogues as potential treatments for various cancers including melanoma. This article discusses the evidence in favour of a role for 1,25-(OH)2D3 in protection against the progression of melanocytic lesions and also summarizes the mechanisms by which 1,2 ...[more]
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