Tag-mass: specific molecular imaging of transcriptome and proteome by mass spectrometry based on photocleavable tag.
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ABSTRACT:
SUBMITTER: Lemaire R
PROVIDER: S-EPMC2947822 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Publications
Tag-mass: specific molecular imaging of transcriptome and proteome by mass spectrometry based on photocleavable tag.
Lemaire R R Stauber J J Wisztorski M M Van Camp C C Desmons A A Deschamps M M Proess G G Rudlof I I Woods A S AS Day R R Salzet M M Fournier I I
Journal of proteome research 20070504 6
MALDI tissue imaging of tissues has become a promising technique for tracking biomarkers while determining their location and structural characterization. We have now developed specific targeting probes (oligonucleotides, antibodies), named Tag-Mass. This approach is based on probes modified with a photocleavable linker coupled with a tag cleaved and detected using mass spectrometry. Tag-Mass development is the key for a rapid, sensitive, and accurate approach to correlate levels of expression o ...[more]
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