Ontology highlight
ABSTRACT:
SUBMITTER: Rawat VP
PROVIDER: S-EPMC2947867 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Rawat Vijay P S VP Arseni Natalia N Ahmed Farid F Mulaw Medhanie A MA Thoene Silvia S Heilmeier Bernhard B Sadlon Tim T D'Andrea Richard J RJ Hiddemann Wolfgang W Bohlander Stefan K SK Buske Christian C Feuring-Buske Michaela M
Proceedings of the National Academy of Sciences of the United States of America 20100910 39
Recent data indicate that a variety of regulatory molecules active in embryonic development may also play a role in the regulation of early hematopoiesis. Here we report that the human Vent-like homeobox gene VENTX, a putative homolog of the Xenopus xvent2 gene, is a unique regulatory hematopoietic gene that is aberrantly expressed in CD34(+) leukemic stem-cell candidates in human acute myeloid leukemia (AML). Quantitative RT-PCR documented expression of the gene in lineage positive hematopoieti ...[more]