Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC2948081 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Yu J J Cao Q Q Yu J J Wu L L Dallol A A Li J J Chen G G Grasso C C Cao X X Lonigro R J RJ Varambally S S Mehra R R Palanisamy N N Wu J Y JY Latif F F Chinnaiyan A M AM
Oncogene 20100712 39
The neuronal repellent SLIT2 is repressed in a number of cancer types primarily through promoter hypermethylation. SLIT2, however, has not been studied in prostate cancer. Through genome-wide location analysis we identified SLIT2 as a target of polycomb group (PcG) protein EZH2. The EZH2-containing polycomb repressive complexes bound to the SLIT2 promoter inhibiting its expression. SLIT2 was downregulated in a majority of metastatic prostate tumors, showing a negative correlation with EZH2. This ...[more]