CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC2948471 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury.
Wang Ying Y Zhao Jing J Kalsotra Auinash A Turman Cheri M CM Grill Raymond J RJ Dash Pramod K PK Strobel Henry W HW
Journal of neurotrauma 20081001 10
Cytochrome P450 (CYP) 4Fs constitute a subgroup of the cytochrome P450 superfamily and are involved in cellular protection and metabolism of numerous molecules, including drugs, toxins, and eicosanoids. CYP4Fs are widely distributed in rat brain with each isoform having a unique distribution pattern throughout different brain regions. The present study shows that traumatic brain injury (TBI) triggers inflammation and elicits changes in mRNA expression of CYP4Fs in the frontal and occipital lobes ...[more]
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