Ontology highlight
ABSTRACT:
SUBMITTER: Siepmann M
PROVIDER: S-EPMC2948513 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Siepmann Martin M Kumar Sathish S Mayer Günter G Walter Jochen J
PloS one 20101001 10
Neprilysin (NEP) is a type II membrane metalloproteinase that cleaves physiologically active peptides at the cell surface thus regulating the local concentration of these peptides available for receptor binding and signal transduction. In addition, the cytoplasmic N-terminal domain of NEP interacts with the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) thereby regulating intracellular signaling via Akt. Thus, NEP serves dual functions in extracellular and intracellular signal ...[more]