Ontology highlight
ABSTRACT:
SUBMITTER: Zhao D
PROVIDER: S-EPMC2948946 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Zhao Dongmei D Zhao Xiuhua X Zu Yuangang Y Li Jialei J Zhang Yu Y Jiang Ru R Zhang Zhonghua Z
International journal of nanomedicine 20100920
Paclitaxel (Taxol(®)) is an important anticancer drug in clinical use for treatment of a variety of cancers. Because of its low solubility, it is formulated in high concentration in Cremophor EL(®) which induces hypersensitivity reactions. In this study, targeted delivery of paclitaxel-loaded nanoparticles was prepared by a desolvation procedure, crosslinked on the wall material of bovine serum albumin, and subsequently decorated by folic acid. The characteristics of the nanoparticles, such as a ...[more]