Ontology highlight
ABSTRACT:
SUBMITTER: Hebbeler AM
PROVIDER: S-EPMC2948954 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Hebbeler Andrew M AM Cairo Cristiana C Cummings Jean Saville JS Pauza C David CD
Cancer immunology, immunotherapy : CII 20061128 6
Human Vgamma2Vdelta2 T cells exhibit T cell receptor-dependent, MHC-unrestricted recognition of antigen and play important roles in tumor and pathogen immunity. To characterize antigen recognition by the Vgamma2Vdelta2 TCR, we used the combined approach of spectratyping and CDR3 sequence analysis that measures changes in the TCR repertoire before and after stimulation with a phosphoantigen (isopentenyl pyrophosphate) or an irradiated tumor cell line (Daudi B lymphoma). Here we describe common Vg ...[more]