Ontology highlight
ABSTRACT:
SUBMITTER: Joo JH
PROVIDER: S-EPMC2949054 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Joo Jeong-Hoon JH Taxter Timothy J TJ Munguba Gustavo C GC Kim Yong H YH Dhaduvai Kanthi K Dunn Nicholas W NW Degan William J WJ Oh S Paul SP Sugrue Stephen P SP
Developmental biology 20100714 2
Pinin (Pnn), a nuclear speckle-associated protein, has been shown to function in maintenance of epithelial integrity through altering expression of several key adhesion molecules. Here we demonstrate that Pnn plays a crucial role in small intestinal development by influencing expression of an intestinal homeobox gene, Cdx2. Conditional inactivation of Pnn within intestinal epithelia resulted in significant downregulation of a caudal type homeobox gene, Cdx2, leading to obvious villus dysmorphoge ...[more]