Ontology highlight
ABSTRACT:
SUBMITTER: Gallezot JD
PROVIDER: S-EPMC2949107 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Gallezot Jean-Dominique JD Nabulsi Nabeel N Neumeister Alexander A Planeta-Wilson Beata B Williams Wendol A WA Singhal Tarun T Kim Sunhee S Maguire R Paul RP McCarthy Timothy T Frost J James JJ Huang Yiyun Y Ding Yu-Shin YS Carson Richard E RE
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090923 1
[(11)C]P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT(1B)) receptors with positron emission tomography (PET). The purpose of this study was to evaluate [(11)C]P943 for this application in humans, and to determine the most suitable quantification method. Positron emission tomography data and arterial input function measurements were acquired in a cohort of 32 human subjects. Using arterial input functions, compartmental modeling, the Logan g ...[more]