Ontology highlight
ABSTRACT:
SUBMITTER: Faghihi MA
PROVIDER: S-EPMC2949395 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Faghihi Mohammad Ali MA Kocerha Jannet J Modarresi Farzaneh F Engström Pär G PG Chalk Alistair M AM Brothers Shaun P SP Koesema Eric E St Laurent Georges G Wahlestedt Claes C
PloS one 20101004 10
Natural antisense transcripts represent a class of regulatory RNA molecules, which are characterized by their complementary sequence to another RNA transcript. Extensive sequencing efforts suggest that natural antisense transcripts are prevalent throughout the mammalian genome; however, their biological significance has not been well defined. We performed a loss-of-function RNA interference (RNAi) screen, which targeted 797 evolutionary conserved antisense transcripts, and found evidence for a r ...[more]