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ABSTRACT:
SUBMITTER: Mieszawska AJ
PROVIDER: S-EPMC2949442 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Mieszawska Aneta J AJ Fourligas Nikolaos N Georgakoudi Irene I Ouhib Nadia M NM Belton David J DJ Perry Carole C CC Kaplan David L DL
Biomaterials 20101201 34
Osteoinductive and biodegradable composite biomaterials for bone regeneration were prepared by combining silk fibroin with silica particles. The influence of these composite systems on osteogenesis was evaluated with human mesenchymal stem cells (hMSCs) subjected to osteogenic differentiation. hMSCs adhered, proliferated, and differentiated towards osteogenic lineages on silk/silica films. The addition of the silica to the silk films influenced gene expression leading to upregulation of bone sia ...[more]