Dataset Information

Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians.

ABSTRACT: The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area.The aim of this study is to determine the seroprevalence of HBV and HCV virus in HIV-infected subjects in the Gambia.Plasma samples from HIV infected patients (190 individuals with clinically defined AIDS and 382 individuals without AIDS) were tested retrospectively for the presence of HBV sero-markers and for serum HBV DNA, screened for HCV infection by testing for anti-HCV antibody and HCV RNA.HBsAg prevalence in HIV-positive individuals is 12.2%. HIV/HBV co-infected individuals with CD4 count of <200 cells µL?¹ have a higher HBV DNA viral load than patients with higher CD4 count (log 4.0 vs. log 2.0 DNA copies/ml, p < 0.05). Males (OR = 1.8, 95% CI: 1.0, 3.2) were more likely to be HBsAg positive than female. HCV seroprevalence was 0.9% in HIV-positive individuals.The prevalence of HBsAg carriage in HIV- infected Gambians is similar to that obtained in the general population. However co-infected individuals with reduced CD4 levels, indicative of AIDS had higher prevalence of HBeAg retention and elevated HBV DNA levels compared to non-AIDS patients with higher CD4 count.

SUBMITTER: Jobarteh M

PROVIDER: S-EPMC2949835 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians.

Jobarteh Modou M Malfroy Marine M Peterson Ingrid I Jeng Adam A Sarge-Njie Ramu R Alabi Abraham A Peterson Kevin K Cotten Matt M Hall Andrew A Rowland-Jones Sarah S Whittle Hilton H Tedder Richard R Jaye Assan A Mendy Maimuna M

Virology journal 20100915

<h4>Background</h4>The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area.<h4>Objective</h4>The aim of this study is to determine the seroprevalence of HBV and HCV virus in HIV-infected subjects in the Gambia.<h4>Methods</h4>Plasma samples from HIV infected patients (190 individuals with clinically defined AIDS and 382 individuals without AIDS) were tested retrospectively for the presence of HBV sero-markers and ...[more]

PMID: 20843322

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Dataset Information

Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians.

Publications

Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians.

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