Ontology highlight
ABSTRACT:
SUBMITTER: Bridgham JT
PROVIDER: S-EPMC2950128 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Bridgham Jamie T JT Eick Geeta N GN Larroux Claire C Deshpande Kirti K Harms Michael J MJ Gauthier Marie E A ME Ortlund Eric A EA Degnan Bernard M BM Thornton Joseph W JW
PLoS biology 20101005 10
Understanding how protein structures and functions have diversified is a central goal in molecular evolution. Surveys of very divergent proteins from model organisms, however, are often insufficient to determine the features of ancestral proteins and to reveal the evolutionary events that yielded extant diversity. Here we combine genomic, biochemical, functional, structural, and phylogenetic analyses to reconstruct the early evolution of nuclear receptors (NRs), a diverse superfamily of transcri ...[more]